Lymphocyte migration in health and inflammatory rheumatic disease
Identifieur interne : 002020 ( Main/Exploration ); précédent : 002019; suivant : 002021Lymphocyte migration in health and inflammatory rheumatic disease
Auteurs : Nicholas Manolios [États-Unis] ; Carolyn Geczy [Australie] ; Leslie Schrieber [Australie]Source :
- Seminars in Arthritis and Rheumatism [ 0049-0172 ] ; 1991.
English descriptors
- Teeft :
- Adhesion, Arthritis rheum, Autoimmune, Cytokine, Duct, Endothelial, Endothelial cells, Endothelium, Geczy, Glycoprotein, Hevs, Homing, Homing receptors, Huve, Immune, Immunol, Inflamed, Inflamed synovium, Inflammation, Inflammatory, Leukocyte, Lymph, Lymph node, Lymph node cells, Lymph node sections, Lymph nodes, Lymphocyte, Lymphocyte adhesion, Lymphocyte binding, Lymphocyte migration, Lymphocyte recirculation, Lymphocyte traffic, Lymphoid, Lymphoid tissue, Manolios, Migration, Moab, Monoclonal, Monoclonal antibody, Murine, Node, Peripheral lymph node hevs, Receptor, Recirculating, Recirculation, Rheum, Rheumatoid, Rheumatoid arthritis, Rheumatoid synovium, Schrieber, Subset, Synovial, Synovial fluid, Synovium, Thoracic, Transmembrane region, Venule, Ziff.
Abstract
Abstract: Lymphocytes are in a dynamic state of flux moving from the blood stream into lymphoid and extralymphoid tissues and eventually returning to the general circulation. This continuous process permits the full repertoire of lymphocyte specificities to be available for immune reactions. The regulation of lymphocyte traffic to specific tissue locations is complex and involves lymphocyte-endothelial interactions at sites of extravasation. Some of the molecules involved in lymphocyte-endothelial adhesion interactions have now been cloned and sequenced using molecular biology techniques. Lymphocyte migration to chronic inflammatory sites such as rheumatoid synovium shares a number of similarities to that involved in normal organized lymphoid tissue. First, at sites of chronic disease there are marked morphological changes to the vascular endothelium resulting in high endothelial venules identical to those found in normal lymphoid tissue. In addition, there are functional changes in vascular endothelial behavior that are receptor-mediated and regulate lymphocyte traffic to inflamed sites. The nature of these molecules on endothelial cells (addressins) and the regulation of their expression is still unclear. The control of lymphocyte migration appears to be influenced by selective lymphocyte-endothelial recognition in both health and inflammatory disease. The factors that modulate these interactions are reviewed.
Url:
DOI: 10.1016/0049-0172(91)90010-W
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001401
- to stream Istex, to step Curation: 001401
- to stream Istex, to step Checkpoint: 000D62
- to stream Main, to step Merge: 002119
- to stream Main, to step Curation: 002020
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Lymphocyte migration in health and inflammatory rheumatic disease</title><author><name sortKey="Manolios, Nicholas" sort="Manolios, Nicholas" uniqKey="Manolios N" first="Nicholas" last="Manolios">Nicholas Manolios</name></author><author><name sortKey="Geczy, Carolyn" sort="Geczy, Carolyn" uniqKey="Geczy C" first="Carolyn" last="Geczy">Carolyn Geczy</name></author><author><name sortKey="Schrieber, Leslie" sort="Schrieber, Leslie" uniqKey="Schrieber L" first="Leslie" last="Schrieber">Leslie Schrieber</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4642A729C75E136B7E538A598F8498ADBA1A4571</idno><date when="1991" year="1991">1991</date><idno type="doi">10.1016/0049-0172(91)90010-W</idno><idno type="url">https://api.istex.fr/ark:/67375/6H6-MXRD2GS4-T/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001401</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001401</idno><idno type="wicri:Area/Istex/Curation">001401</idno><idno type="wicri:Area/Istex/Checkpoint">000D62</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000D62</idno><idno type="wicri:doubleKey">0049-0172:1991:Manolios N:lymphocyte:migration:in</idno><idno type="wicri:Area/Main/Merge">002119</idno><idno type="wicri:Area/Main/Curation">002020</idno><idno type="wicri:Area/Main/Exploration">002020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Lymphocyte migration in health and inflammatory rheumatic disease</title><author><name sortKey="Manolios, Nicholas" sort="Manolios, Nicholas" uniqKey="Manolios N" first="Nicholas" last="Manolios">Nicholas Manolios</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Cell Biology and Cell Metabolism Branch, National Institutes of Child Health and Development, Bethesda, MD</wicri:regionArea><placeName><region type="state">Maryland</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Geczy, Carolyn" sort="Geczy, Carolyn" uniqKey="Geczy C" first="Carolyn" last="Geczy">Carolyn Geczy</name><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>The Heart Research Institute, Camperdown, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">Australie</country><wicri:regionArea>2From the Heart Research Institute, Camperdown, Sydney</wicri:regionArea><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Schrieber, Leslie" sort="Schrieber, Leslie" uniqKey="Schrieber L" first="Leslie" last="Schrieber">Leslie Schrieber</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Address reprint requests to Leslie Schrieber, MD, Sydney University Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW, 2065</wicri:regionArea><wicri:noRegion>2065</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney University Department of Rheumatology, Royal North Shore Hospital, St Leonards</wicri:regionArea><wicri:noRegion>St Leonards</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>3From the Sydney University Department of Rheumatology, Royal North Shore Hospital, St Leonards</wicri:regionArea><wicri:noRegion>St Leonards</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Seminars in Arthritis and Rheumatism</title><title level="j" type="abbrev">YSARH</title><idno type="ISSN">0049-0172</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1991">1991</date><biblScope unit="volume">20</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="339">339</biblScope><biblScope unit="page" to="352">352</biblScope></imprint><idno type="ISSN">0049-0172</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0049-0172</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adhesion</term><term>Arthritis rheum</term><term>Autoimmune</term><term>Cytokine</term><term>Duct</term><term>Endothelial</term><term>Endothelial cells</term><term>Endothelium</term><term>Geczy</term><term>Glycoprotein</term><term>Hevs</term><term>Homing</term><term>Homing receptors</term><term>Huve</term><term>Immune</term><term>Immunol</term><term>Inflamed</term><term>Inflamed synovium</term><term>Inflammation</term><term>Inflammatory</term><term>Leukocyte</term><term>Lymph</term><term>Lymph node</term><term>Lymph node cells</term><term>Lymph node sections</term><term>Lymph nodes</term><term>Lymphocyte</term><term>Lymphocyte adhesion</term><term>Lymphocyte binding</term><term>Lymphocyte migration</term><term>Lymphocyte recirculation</term><term>Lymphocyte traffic</term><term>Lymphoid</term><term>Lymphoid tissue</term><term>Manolios</term><term>Migration</term><term>Moab</term><term>Monoclonal</term><term>Monoclonal antibody</term><term>Murine</term><term>Node</term><term>Peripheral lymph node hevs</term><term>Receptor</term><term>Recirculating</term><term>Recirculation</term><term>Rheum</term><term>Rheumatoid</term><term>Rheumatoid arthritis</term><term>Rheumatoid synovium</term><term>Schrieber</term><term>Subset</term><term>Synovial</term><term>Synovial fluid</term><term>Synovium</term><term>Thoracic</term><term>Transmembrane region</term><term>Venule</term><term>Ziff</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Lymphocytes are in a dynamic state of flux moving from the blood stream into lymphoid and extralymphoid tissues and eventually returning to the general circulation. This continuous process permits the full repertoire of lymphocyte specificities to be available for immune reactions. The regulation of lymphocyte traffic to specific tissue locations is complex and involves lymphocyte-endothelial interactions at sites of extravasation. Some of the molecules involved in lymphocyte-endothelial adhesion interactions have now been cloned and sequenced using molecular biology techniques. Lymphocyte migration to chronic inflammatory sites such as rheumatoid synovium shares a number of similarities to that involved in normal organized lymphoid tissue. First, at sites of chronic disease there are marked morphological changes to the vascular endothelium resulting in high endothelial venules identical to those found in normal lymphoid tissue. In addition, there are functional changes in vascular endothelial behavior that are receptor-mediated and regulate lymphocyte traffic to inflamed sites. The nature of these molecules on endothelial cells (addressins) and the regulation of their expression is still unclear. The control of lymphocyte migration appears to be influenced by selective lymphocyte-endothelial recognition in both health and inflammatory disease. The factors that modulate these interactions are reviewed.</div></front></TEI><affiliations><list><country><li>Australie</li><li>États-Unis</li></country><region><li>Maryland</li><li>Nouvelle-Galles du Sud</li></region><settlement><li>Sydney</li></settlement></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Manolios, Nicholas" sort="Manolios, Nicholas" uniqKey="Manolios N" first="Nicholas" last="Manolios">Nicholas Manolios</name></region></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Geczy, Carolyn" sort="Geczy, Carolyn" uniqKey="Geczy C" first="Carolyn" last="Geczy">Carolyn Geczy</name></region><name sortKey="Geczy, Carolyn" sort="Geczy, Carolyn" uniqKey="Geczy C" first="Carolyn" last="Geczy">Carolyn Geczy</name><name sortKey="Schrieber, Leslie" sort="Schrieber, Leslie" uniqKey="Schrieber L" first="Leslie" last="Schrieber">Leslie Schrieber</name><name sortKey="Schrieber, Leslie" sort="Schrieber, Leslie" uniqKey="Schrieber L" first="Leslie" last="Schrieber">Leslie Schrieber</name><name sortKey="Schrieber, Leslie" sort="Schrieber, Leslie" uniqKey="Schrieber L" first="Leslie" last="Schrieber">Leslie Schrieber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002020 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002020 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= H2N2V1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:4642A729C75E136B7E538A598F8498ADBA1A4571
|texte= Lymphocyte migration in health and inflammatory rheumatic disease
}}
| This area was generated with Dilib version V0.6.33. |  |